As part of efforts towards implementing recommendations by UNESCO’s global consultation on open science, the Knowledge Equity Lab (KEL) at the University of Toronto Scarborough has been conducting a mapping exercise to better understand the implementation challenges of sustaining open knowledge infrastructure faced by regional research communities. Building on the analysis, this event will serve as a venue for ideas about open infrastructure to take root and flourish. We will be inviting participants from diverse communities to co-design concrete, actionable strategies and ways to sustain local and interoperable infrastructures that are free from corporate control and technical standards often imposed by institutions in the global north. We anticipate event outcomes will include a number of use cases, along with potential funding support, partnership and sustainability plans.